Ramírez-Amador V, Esquivel-Pedraza L, Mohar A, Reynoso-Gómez E, Volkow-Fernández P, Guarner J, Sánchez-Mejorada G
Department of Health Care, Universidad Autonoma Metropolitana-Xochimilco, Mexico City, Mexico.
Eur J Cancer B Oral Oncol. 1996 Sep;32B(5):322-7. doi: 10.1016/0964-1955(96)00020-6.
In order to determine the incidence rate of oral lesions associated with chemotherapy, as well as well as its association with clinical and laboratory parameters and potential risk factors, 50 in-patients with non-Hodgkin's lymphoma or leukaemia under chemotherapy were followed from January 1993 to May 1994. Basal and weekly oral examinations were performed. Clinical and laboratory data were registered. Wilcoxon's rank sum test, chi square test, univariate and multivariate logistic regression analyses were used, 36 individuals with leukaemia and 14 with non-Hodgkin's lymphoma were followed for 158 weeks; mean age was 33 years (range 15-85). Oral lesion incidence rate was 45/100 patients-week. Exfoliative cheilitis and infections (herpes and candidosis) were the most common oral complications, followed by haemorrhagic lesions and mucositis. Haemorrhagic lesions correlated with thrombocytopenia (RR = 30.5). Etoposide administration (RR = 8.6), alkylating agents (RR = 15.6), a prior course of chemotherapy (RR = 23.2) and neutropenia (RR = 4.16) were predictors of mucositis. Oral lesions were a common complication in this study, and a possible association of mucositis with several factors is suggested.
为了确定与化疗相关的口腔病变的发病率，以及其与临床和实验室参数及潜在风险因素的关联，1993年1月至1994年5月对50例接受化疗的非霍奇金淋巴瘤或白血病住院患者进行了随访。进行了基础口腔检查和每周一次的口腔检查。记录了临床和实验室数据。采用威尔科克森秩和检验、卡方检验、单因素和多因素逻辑回归分析，对36例白血病患者和14例非霍奇金淋巴瘤患者进行了158周的随访；平均年龄为33岁（范围15 - 85岁）。口腔病变发病率为45/100患者 - 周。剥脱性唇炎和感染（疱疹和念珠菌病）是最常见的口腔并发症，其次是出血性病变和粘膜炎。出血性病变与血小板减少相关（相对危险度 = 30.5）。使用依托泊苷（相对危险度 = 8.6）、烷化剂（相对危险度 = 15.6）、先前的化疗疗程（相对危险度 = 23.2）和中性粒细胞减少（相对危险度 = 4.16）是粘膜炎的预测因素。在本研究中口腔病变是常见并发症，提示粘膜炎可能与多种因素有关。
