Twisk J W, Kemper H C, Mellenbergh G J, van Mechelen W
Institute for Research in Extramural Medicine, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands.
J Epidemiol Community Health. 1996 Oct;50(5):505-11. doi: 10.1136/jech.50.5.505.
To analyse the relation between the longitudinal development of total serum cholesterol (TC), high density lipoprotein cholesterol (HDL), and the TC/ HDL ratio and the longitudinal development of the biological parameters body fatness (SSF), lean body mass (LBM), and cardiopulmonary fitness (VO2-max). The relations were analysed with generalised estimating equations (GEE).
The relations were investigated with data from the Amsterdam growth and health study, a longitudinal study in which six measurements were carried out within a period of 15 years.
Altogether 98 females and 84 males aged 13 years at the start of the study.
Adjusted for lifestyle and other biological parameters, the longitudinal development of TC was inversely related to the development of LBM (standardised regression coefficient beta = -0.27; p < or = 0.01) and positively to SSF (beta males = 0.32; p < or = 0.01 and beta females = 0.15; p < or = 0.01). HDL was inversely related to LBM (beta = -0.26; p < or = 0.01) and positively to VO2-max (beta = 0.08; p < or = 0.05). The TC/HDL ratio was positively related to SSF (beta males = 0.39; p < or = 0.01 and beta females = 0.13; p < or = 0.01) and inversely to VO2-max (beta = -0.09; p < or = 0.05).
The longitudinal analyses showed that body fatness was related to a high risk profile with respect to hypercholesterolaemia, and cardiopulmonary fitness to a low risk profile. Furthermore, it was shown that using body mass index as an indicator of body fatness in relation to lipoprotein values, has some important drawbacks.
分析总血清胆固醇（TC）、高密度脂蛋白胆固醇（HDL）以及TC/HDL比值的纵向变化与身体脂肪量（SSF）、瘦体重（LBM）和心肺适能（最大摄氧量，VO2-max）等生物学参数的纵向变化之间的关系。采用广义估计方程（GEE）分析这些关系。
利用阿姆斯特丹生长与健康研究的数据对这些关系进行了调查，该纵向研究在15年内进行了6次测量。
研究开始时共有98名女性和84名男性，年龄均为13岁。
在对生活方式和其他生物学参数进行校正后，TC的纵向变化与LBM的变化呈负相关（标准化回归系数β=-0.27；p≤0.01），与SSF呈正相关（男性β=0.32；p≤0.01，女性β=0.15；p≤0.01）。HDL与LBM呈负相关（β=-0.26；p≤0.01），与VO2-max呈正相关（β=0.08；p≤0.05）。TC/HDL比值与SSF呈正相关（男性β=0.39；p≤0.01，女性β=0.13；p≤0.01），与VO2-max呈负相关（β=-0.09；p≤0.05）。
纵向分析表明，身体脂肪量与高胆固醇血症的高风险特征相关，而心肺适能与低风险特征相关。此外，研究表明，将体重指数用作与脂蛋白值相关的身体脂肪量指标存在一些重要缺陷。
