Guo S, Beckett L, Chumlea W C, Roche A F, Siervogel R M
Department of Community Health, Wright State University, School of Medicine, Yellow Springs, OH 45387-1695.
Am J Clin Nutr. 1993 Jul;58(1):61-7. doi: 10.1093/ajcn/58.1.61.
Total cholesterol (TC) and low-density- (LDL-C) and high-density-lipoprotein cholesterol (HDL-C) concentrations were recorded annually from 9 to 21 y of age to study tracking and predictive values for adulthood lipid concentrations associated with cardiovascular disease. The tracking coefficients for TC and LDL-C were congruent to 0.7 for 4-, 6-, and 12-y intervals, indicating good predictive value at ages 9-11 y for risk of elevated concentrations at ages 19-21 y. Tracking of HDL-C was less marked but the patterns were similar. The risk ratios for high concentrations at 19-21 y were 3.8 for TC, 2.6 for LDL-C, and 4 for HDL-C for 9-y-olds with values of 5.17 mmol/L for TC, 3.36 mmol/L for LDL-C, and 0.90 mmol/L for HDL-C, relative to 9-y-olds with values of 4.65 mmol/L for TC, 2.84 mmol/L for LDL-C, and 1.29 mmol/L for HDL-C.
从9岁至21岁每年记录总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）的浓度，以研究与心血管疾病相关的成年期血脂浓度的追踪情况和预测价值。TC和LDL-C在4年、6年和12年间隔的追踪系数均等于0.7，表明9至11岁时的血脂浓度对19至21岁时浓度升高风险具有良好的预测价值。HDL-C的追踪情况不太明显，但模式相似。对于9岁时TC值为5.17 mmol/L、LDL-C值为3.36 mmol/L、HDL-C值为0.90 mmol/L的儿童，相对于9岁时TC值为4.65 mmol/L、LDL-C值为2.84 mmol/L、HDL-C值为1.29 mmol/L的儿童，19至21岁时高浓度的风险比分别为：TC为3.8，LDL-C为2.6，HDL-C为4。
