Phelps D L, Karim A
J Pharm Sci. 1977 Aug;66(8):1203. doi: 10.1002/jps.2600660841.
The concentration of canrenone, a principal metabolite of spironolactone, was determined in human serum and milk. The milk to serum concentration ratios of this metabolite were 0.72 at 2 hr and 0.51 at 14.5 hr after ingestation of spironolactone. It was estimated that the maximum quantity of canrenone ingested daily by a human infant via its mother's milk would be approximately 0.2% of the daily dose of spironolactone given to the mother.
测定了螺内酯的主要代谢产物坎利酮在人血清和乳汁中的浓度。摄入螺内酯后2小时，该代谢产物的乳汁与血清浓度比为0.72，14.5小时时为0.51。据估计，人类婴儿通过母乳每日摄入坎利酮的最大量约为母亲服用螺内酯日剂量的0.2%。
