A组链球菌从宿主蛋白中获取铁。
Acquisition of iron from host proteins by the group A streptococcus.
作者信息
Eichenbaum Z, Muller E, Morse S A, Scott J R
机构信息
Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322, USA.
出版信息
Infect Immun. 1996 Dec;64(12):5428-9. doi: 10.1128/iai.64.12.5428-5429.1996.
Abstract
To identify mammalian iron-binding proteins that can serve as iron sources for Streptococcus pyogenes, the group A streptococcus (GAS), we used a plate assay. Ferritin, hemin, hemoglobin, myoglobin, and catalase can support growth of GAS on iron-depleted medium. However, growth was not detected when iron was provided as iron-saturated transferrin or lactoferrin or bound to cytochrome c. Therefore, it appears that GAS can use the intracellular iron sources available in the human body, which is consistent with its ability to cause tissue destruction during infection.
摘要
为了鉴定可作为化脓性链球菌（A 组链球菌，GAS）铁源的哺乳动物铁结合蛋白，我们采用了平板试验。铁蛋白、血红素、血红蛋白、肌红蛋白和过氧化氢酶能够支持 GAS 在缺铁培养基上生长。然而，当铁以铁饱和转铁蛋白或乳铁蛋白形式提供或与细胞色素 c 结合时，未检测到生长。因此，似乎 GAS 能够利用人体中可用的细胞内铁源，这与其在感染期间导致组织破坏的能力是一致的。
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