Murata H, Ishikawa K, Tenshin S, Horiuchi S, Nakanishi M, Asaoka K, Kawata T, Yamamoto T T
Department of Orthodontics, School of Dentistry, Tokushima University, Japan.
Caries Res. 1996;30(6):465-70. doi: 10.1159/000262361.
Diamine silver fluoride [AgF: (NH3)2AgF] is a unique fluoride solution used clinically in Japan for primary teeth. AgF has been shown to reduce dental caries and dentine hypersensitivity. However, AgF also stains teeth black due to sulfide precipitation and thus is unacceptable for permanent teeth. In the present study, the potential value of ammonium hexafluorosilicate [SiF: (NH4)2SiF6], which has a formula similar to that of AgF but contains no Ag, was studied with respect to its ability to fluoridate apatite. Hydroxyapatite [HAP: Ca10(PO4)6(OH)2] powder was treated with several topical fluoride solutions, i.e. neutral sodium fluoride, acidulated phosphate fluoride (APF) along with AgF and SiF. Following treatment, the HAP powders were analyzed for their fluorine content, crystallinity changes, and solubility in acidic solution. The highest level of fluoridated HAP [FAP: Ca10(PO4)6(OH)xF2-x] was observed in HAP powder treated with SiF, even though more total fluorine in the form of FAP and CaF2 was observed in HAP powder samples treated with APF. Presumably as a consequence of this higher level of FAP formation after SiF treatment, the highest level of crystallinity along with the lowest solubility in acidic solution were observed in HAP powder treated with SiF solution. We concluded, therefore, that SiF may have potential value for use as a topical fluoride solution.
二胺氟化银[AgF:(NH₃)₂AgF]是一种在日本临床上用于乳牙的独特氟化物溶液。已证明AgF可减少龋齿和牙本质过敏。然而，由于硫化物沉淀，AgF也会使牙齿染黑，因此对于恒牙是不可接受的。在本研究中，研究了六氟硅酸铵[SiF:(NH₄)₂SiF₆]的潜在价值，其化学式与AgF相似但不含Ag，研究了其使磷灰石氟化的能力。用几种局部用氟化物溶液处理羟基磷灰石[HAP:Ca₁₀(PO₄)₆(OH)₂]粉末，即中性氟化钠、酸化磷酸氟(APF)以及AgF和SiF。处理后，分析HAP粉末的氟含量、结晶度变化以及在酸性溶液中的溶解度。在用SiF处理的HAP粉末中观察到最高水平的氟化HAP[FAP:Ca₁₀(PO₄)₆(OH)ₓF₂₋ₓ]，尽管在用APF处理的HAP粉末样品中观察到以FAP和CaF₂形式存在的更多总氟。据推测，由于SiF处理后FAP形成水平较高，在用SiF溶液处理的HAP粉末中观察到最高水平的结晶度以及在酸性溶液中的最低溶解度。因此，我们得出结论，SiF可能具有作为局部用氟化物溶液的潜在价值。
