Suge Toshiyuki, Shibata Shingo, Ishikawa Kunio, Matsuo Takashi
Department of Conservative Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Department of Biomaterials, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Am J Dent. 2018 Apr;31(2):103-106.
To evaluate the acid resistance of various antibacterial ammonium hexafluorosilicate (SiF) solutions.
Antibacterial SiF solutions were prepared with the addition of chlorhexidine (CHX), cetylpyridinium chloride (CPC), isopropyl methylphenol (IPMP), or epigallocatechin gallate (EGCG). Hydroxyapatite pellets were treated with SiF solution with or without antibacterial agents for 3 minutes. The demineralized depth of hydroxyapatite pellets after SiF treatment was measured using a surface roughness analyzer.
SiF+CPC solution showed equivalent acid resistance to SiF and AgF treatment. In contrast, the original acid resistance activity of SiF solution was diminished by the addition of other antibacterial agents (CHX, IPMP and EGCG). SiF with the addition of CPC was the most effective for reducing the demineralized depth, showing the same levels as those of SiF and AgF.
The addition of CPC to the SiF solution did not reduce its fluoride activity, indicating that it may be useful for the prevention of dental caries. SiF with added antibacterial agents may have the potential to prevent dental caries.
