TmDOTP5⁻：一种用于体内核磁共振温度测量的物质。

TmDOTP5-: a substance for NMR temperature measurements in vivo.

作者信息

Zuo C S, Bowers J L, Metz K R, Nosaka T, Sherry A D, Clouse M E

机构信息

Department of Radiological Sciences, Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.

出版信息

Magn Reson Med. 1996 Dec;36(6):955-9. doi: 10.1002/mrm.1910360619.

DOI:10.1002/mrm.1910360619

PMID:8946362

Abstract

The chemical shifts of 31P and 1H in thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylene phosphonate) (TmDOTP5-) are approximately two orders of magnitude more sensitive to temperature than are water proton and 19F shifts. In the physiologically relevant pH range, the 31P and 1H chemical shifts of TmDOTP5- are linear functions of temperature between 25 and 47 degrees C. The results indicate that using TmDOTP5- can provide measurements of temperature in vivo that are significantly more accurate than methods based on water and fluorocarbon chemical shifts.

摘要

铥-1,4,7,10-四氮杂环十二烷-1,4,7,10-四（亚甲基膦酸）（TmDOTP5-）中31P和1H的化学位移对温度的敏感性比水质子和19F位移大约高两个数量级。在生理相关的pH范围内，TmDOTP5-的31P和1H化学位移在25至47摄氏度之间是温度的线性函数。结果表明，使用TmDOTP5-可以提供比基于水和氟碳化合物化学位移的方法更准确的体内温度测量。