Romero P V, Lopez-Aguilar J, Zin W A
Servei de Pneumologia, Hospital Universitari de Bellvitge, Spain.
Respir Physiol. 1996 Oct;106(1):57-63. doi: 10.1016/0034-5687(96)00048-5.
In eight anesthetized, spontaneously breathing New Zealand rabbits airflow, tidal volume, tracheal and esophageal pressures were measured. Frequency, inspiratory and expiratory durations, respiratory system and lung resistances, and elastances, total postinspiratory muscle pressure and its timing parameters were determined. The measurements were performed: (a) under control condition; (b) continuously, during the first 90 sec of the inhalation of a mixture of 5% CO2 + 95% O2, (carbogen, CI); and (c) 6 min after the start of CI. During CI both lung resistance and elastance decreased, and inspiratory driving pressure and postinspiratory muscle pressure increased. No modification could be detected in either the pattern or the duration of postinspiratory muscle activity. In conclusion, mechanical changes precede and facilitate the ventilatory adjustment to CO2 in rabbits.
在八只麻醉状态下自主呼吸的新西兰兔身上，测量了气流、潮气量、气管和食管压力。测定了频率、吸气和呼气持续时间、呼吸系统和肺阻力及弹性、吸气后肌肉总压力及其时间参数。测量在以下情况下进行：(a) 对照条件下；(b) 在吸入5%二氧化碳+95%氧气的混合气（卡波金，CI）的前90秒内连续测量；(c) CI开始后6分钟。在CI期间，肺阻力和弹性均降低，吸气驱动压力和吸气后肌肉压力增加。在吸气后肌肉活动的模式或持续时间方面均未检测到改变。总之，机械变化先于并促进了兔对二氧化碳的通气调节。
