Dries D J
Department of Surgery, Loyola University Medical Center, Maywood, Illinois 60153, USA.
Shock. 1996 Nov;6(5):311-6. doi: 10.1097/00024382-199611000-00001.
While the mechanism remains unclear, a growing body of experimental and clinical evidence suggests that aggressive crystalloid resuscitation in near fatal uncontrolled hemorrhage is associated with poor outcome. Limited attempts to restore blood pressure improve cardiac output, tissue perfusion, and survival while attempts to restore normal tension with crystalloid result in increased hemorrhage volume and higher mortality. The current standard of therapy for treatment of hemorrhagic shock includes initial aggressive crystalloid resuscitation. This mini-review summarizes some of the experimental and clinical data suggesting that this approach may not be desirable in the presence of uncontrolled hemorrhage following injury.
虽然其机制尚不清楚，但越来越多的实验和临床证据表明，在近乎致命的未控制出血情况下进行积极的晶体液复苏与不良预后相关。有限的恢复血压的尝试可改善心输出量、组织灌注和生存率，而用晶体液恢复正常血压的尝试则会导致出血量增加和死亡率升高。目前治疗失血性休克的标准疗法包括初始积极的晶体液复苏。这篇综述总结了一些实验和临床数据，表明在受伤后存在未控制出血的情况下，这种方法可能并不理想。
