前列腺素及其类似物。15. dl-11-脱氧-15-或16-烷基前列腺素的合成与支气管扩张活性
Prostaglandins and congeners. 15. Synthesis and bronchodilator activity of dl-11-deoxy-15- or 16-alkylprostaglandins.
作者信息
Skotnicki J S, Schaub R E, Bernady K F, Siuta G J, Poletto J F, Weiss M J
出版信息
J Med Chem. 1977 Dec;20(12):1551-7. doi: 10.1021/jm00222a003.
PMID:592319
Abstract
The synthesis of dl-11-doxy-15- or 16-alkylprostaglandins by the conjugate addition of appropriately substituted lithium alanate or lithium cuprate reagents to several cyclopentenones is described as is the preparation of the requisite intermediate (E)-1-iodo-1-alkenyl compounds 4, 22, 23, and 31. The bronchodilator activity of these prostaglandin congeners is presented.
摘要
描述了通过将适当取代的铝酸锂或铜酸锂试剂共轭加成到几种环戊烯酮上来合成dl-11-去氧-15-或16-烷基前列腺素，以及制备所需的中间体（E）-1-碘-1-烯基化合物4、22、23和31的方法。还介绍了这些前列腺素类似物的支气管扩张活性。
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