前列腺素及其类似物。16. 外消旋-11-脱氧-3-硫代前列腺素的合成及支气管扩张活性
Prostaglandins and congeners. 16. Synthesis and bronchodilator activity of dl-11-doexy-3-thiaprostaglandins.
作者信息
Skotnicki J S, Schaub R E, Weiss M J, Dessy F
出版信息
J Med Chem. 1977 Dec;20(12):1662-5. doi: 10.1021/jm00222a024.
PMID:592330
Abstract
The interesting bronchodilator activity of certain dl-11-deoxy-3-thiaprostaglandins and their preparation by the conjugate addition of appropriately substituted (E)-1-alkenyllithio cuprate reagents to requisite cyclopentenones are described.
摘要
某些dl-11-脱氧-3-硫代前列腺素有趣的支气管扩张活性及其通过将适当取代的（E）-1-链烯基锂铜试剂共轭加成到所需环戊烯酮来制备的方法被描述。
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