Kerkhof M, Droste J H, de Monchy J G, Schouten J P, Rijcken B
Department of Epidemiology and Statistics, University of Groningen, Groningen, The Netherlands.
Allergy. 1996 Nov;51(11):770-6. doi: 10.1111/j.1398-9995.1996.tb00021.x.
To describe the distribution of serum total IgE and specific IgE to common aeroallergens by sex and age and to study their relationship to each other, we measured serum total IgE and specific IgE (CAP) to house-dust mite, timothy grass, cat, birch, and Cladosporium in a random sample of 2496 subjects, aged 20-70 years from the Dutch general population. We found that total IgE was higher in men, independently of smoking, and that total IgE had no relationship with age after adjustment for specific IgE and smoking in linear regression analysis. At least one positive specific IgE test was found in 32% in both sexes. Men had higher prevalences of specific IgE to house-dust mite and lower prevalences of specific IgE to birch than women. The proportion with positive specific IgE decreased with age. The mean total IgE increased with the number of positive specific IgE tests. Thus, total IgE is higher in men and has no relationship with age if specific IgE is taken into account. The prevalences of specific IgE to aeroallergens are high and decrease with increasing age. We suggest that sex differences in total IgE should be considered when using total IgE.
为描述血清总IgE及对常见气传变应原特异性IgE在性别和年龄上的分布情况，并研究它们之间的相互关系，我们对来自荷兰普通人群的2496名年龄在20至70岁之间的受试者进行随机抽样，检测了血清总IgE以及针对屋尘螨、梯牧草、猫、桦树和枝孢菌的特异性IgE（CAP）。我们发现，男性的总IgE水平更高，且与吸烟无关；在进行线性回归分析并校正特异性IgE和吸烟因素后，总IgE与年龄无关。男女中均有32%的人至少一项特异性IgE检测呈阳性。男性对屋尘螨特异性IgE的患病率高于女性，而对桦树特异性IgE的患病率低于女性。特异性IgE阳性的比例随年龄增长而降低。总IgE平均值随特异性IgE阳性检测次数的增加而升高。因此，如果考虑特异性IgE，男性的总IgE水平更高且与年龄无关。气传变应原特异性IgE的患病率较高且随年龄增长而降低。我们建议在使用总IgE时应考虑总IgE的性别差异。
