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The role of neoadjuvant androgen deprivation prior to radical prostatectomy.

作者信息

Fradet Y

机构信息

Department of Urology, Laval University Cancer Research Center, Hôtel-Dieu de Québec, Canada.

出版信息

Urol Clin North Am. 1996 Nov;23(4):575-85. doi: 10.1016/s0094-0143(05)70337-2.

DOI:10.1016/s0094-0143(05)70337-2
PMID:8948412
Abstract

Androgen ablation prior to radical prostatectomy currently is under investigation with the goal of improving cancer control in patients with clinically treated localized prostate cancer. Results of several randomized studies have shown a significant pathologic downstaging and a decrease in the rate of positive surgical margins using neoadjuvant therapy in stage B cancers. Despite theoretic advantages, neoadjuvant therapy may have side effects and is associated with costs. Until long-term results of biologic and clinical failure rates are available, this approach should be considered investigational.

摘要

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