• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway.

作者信息

Mitch W E, Goldberg A L

机构信息

Renal Division, Emory University School of Medicine, Atlanta, GA 30322, USA.

出版信息

N Engl J Med. 1996 Dec 19;335(25):1897-905. doi: 10.1056/NEJM199612193352507.

DOI:10.1056/NEJM199612193352507
PMID:8948566
Abstract
摘要

相似文献

1
Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway.肌肉萎缩的机制。泛素-蛋白酶体途径的作用。
N Engl J Med. 1996 Dec 19;335(25):1897-905. doi: 10.1056/NEJM199612193352507.
2
Cellular mechanisms controlling protein degradation in catabolic states.
Miner Electrolyte Metab. 1997;23(3-6):194-7.
3
Protein degradation by proteasomes: molecular mechanisms of muscle catabolism.
Nephrol Dial Transplant. 1997 Jan;12(1):13-5. doi: 10.1093/ndt/12.1.13.
4
Muscle wasting in a rat model of long-lasting sepsis results from the activation of lysosomal, Ca2+ -activated, and ubiquitin-proteasome proteolytic pathways.在长期脓毒症大鼠模型中，肌肉消瘦是由溶酶体、钙离子激活的和泛素 - 蛋白酶体蛋白水解途径的激活所致。
J Clin Invest. 1996 Apr 1;97(7):1610-7. doi: 10.1172/JCI118586.
5
Molecular mechanisms regulating protein turnover in muscle.调节肌肉中蛋白质周转的分子机制。
Am J Kidney Dis. 2001 Jan;37(1 Suppl 2):S112-4. doi: 10.1053/ajkd.2001.20764.
6
The ubiquitin-proteasome pathway: on protein death and cell life.泛素-蛋白酶体途径：关乎蛋白质死亡与细胞生命
EMBO J. 1998 Dec 15;17(24):7151-60. doi: 10.1093/emboj/17.24.7151.
7
Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription.胰岛素缺乏型大鼠的肌肉萎缩是由ATP依赖的泛素-蛋白酶体蛋白水解途径激活所致，其机制包括基因转录。
J Clin Invest. 1996 Oct 15;98(8):1703-8. doi: 10.1172/JCI118968.
8
Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states.肌肉蛋白质分解以及泛素-蛋白酶体途径在正常和疾病状态下的关键作用。
J Nutr. 1999 Jan;129(1S Suppl):227S-237S. doi: 10.1093/jn/129.1.227S.
9
Ubiquitin-proteasome-dependent proteolysis in skeletal muscle.骨骼肌中泛素 - 蛋白酶体依赖性蛋白水解作用
Reprod Nutr Dev. 1998 Mar-Apr;38(2):153-65. doi: 10.1051/rnd:19980202.
10
Ubiquitin/proteasome system.泛素/蛋白酶体系统
Nat Biotechnol. 2000 Aug;18(8):807. doi: 10.1038/78325.

引用本文的文献

1
O-GlcNAcase Inhibitor Improves Denervation-Induced Muscle Atrophy in Mice.O-连接的N-乙酰葡糖胺酶抑制剂可改善小鼠去神经支配诱导的肌肉萎缩
J Cachexia Sarcopenia Muscle. 2025 Oct;16(5):e70066. doi: 10.1002/jcsm.70066.
2
The Influence of Irisin on Selected Organs-The Liver, Kidneys, and Lungs: The Role of Physical Exercise.鸢尾素对特定器官——肝脏、肾脏和肺的影响：体育锻炼的作用
Cells. 2025 Aug 8;14(16):1228. doi: 10.3390/cells14161228.
3
Protective Efficacy of Postbiotic beLP-K in a Dexamethasone-Induced Sarcopenia Model.后生元beLP-K在地塞米松诱导的肌肉减少症模型中的保护作用
Int J Mol Sci. 2025 Aug 3;26(15):7504. doi: 10.3390/ijms26157504.
4
Associations of obesity, sarcopenia, and sarcopenic obesity with the risk of kidney stones in the U.S. Adult: results from NHANES 2011-2018.美国成年人中肥胖、肌肉减少症和肌肉减少性肥胖与肾结石风险的关联：2011 - 2018年美国国家健康与营养检查调查结果
Urolithiasis. 2025 Jun 11;53(1):111. doi: 10.1007/s00240-025-01783-4.
5
Predictive model for sarcopenia in chronic kidney disease: a nomogram and machine learning approach using CHARLS data.慢性肾脏病肌少症的预测模型：基于中国健康与养老追踪调查（CHARLS）数据的列线图和机器学习方法
Front Med (Lausanne). 2025 Mar 12;12:1546988. doi: 10.3389/fmed.2025.1546988. eCollection 2025.
6
Protein-energy wasting in chronic kidney disease: mechanisms responsible for loss of muscle mass and function.慢性肾脏病中的蛋白质 - 能量消耗：肌肉质量和功能丧失的相关机制
Kidney Res Clin Pract. 2025 Sep;44(5):726-740. doi: 10.23876/j.krcp.24.214. Epub 2025 Feb 21.
7
Inflammation mediates the association between muscle mass and accelerated phenotypic aging: results from the NHANES 2011-2018.炎症介导肌肉量与加速的表型衰老之间的关联：2011 - 2018年美国国家健康与营养检查调查结果
Front Nutr. 2025 Jan 6;11:1503702. doi: 10.3389/fnut.2024.1503702. eCollection 2024.
8
From molecular to physical function: The aging trajectory.从分子功能到物理功能：衰老轨迹
Curr Res Physiol. 2024 Dec 16;8:100138. doi: 10.1016/j.crphys.2024.100138. eCollection 2025.
9
Daidzein improves muscle atrophy caused by lovastatin by regulating the AMPK/FOXO3a axis.大豆苷元通过调节AMPK/FOXO3a轴改善洛伐他汀引起的肌肉萎缩。
Chin Med. 2024 Dec 31;19(1):180. doi: 10.1186/s13020-024-01034-5.
10
Skeletal muscle reprogramming enhances reinnervation after peripheral nerve injury.骨骼肌重编程增强周围神经损伤后的神经再支配。
Nat Commun. 2024 Oct 25;15(1):9218. doi: 10.1038/s41467-024-53276-4.