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The processing of macronuclear DNA sequences during macronuclear development of the hypotrichous ciliate Stylonychia lemnae.纤毛纲腹毛目纤毛虫细小平列虫大核发育过程中大核DNA序列的处理
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在纤毛亚纲的斜叶拟柱胞藻的分化大核中，内部消除DNA序列的顺序切除

Sequential excision of internal eliminated DNA sequences in the differentiating macronucleus of the hypotrichous ciliate Stylonychia lemnae.

作者信息

Wen J, Maercker C, Lipps H J

机构信息

Institut für Zellbiologie, Universität Witten/Herdecke, Germany.

出版信息

Nucleic Acids Res. 1996 Nov 15;24(22):4415-9. doi: 10.1093/nar/24.22.4415.

DOI:10.1093/nar/24.22.4415
PMID:8948632
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC146267/
Abstract

Elimination of internal eliminated sequences (IES) during macronuclear development of the hypotrichous ciliate Stylonychia lemnae was analyzed in one cluster of macronuclear precursor DNA sequences. The results indicate that IES elimination is a highly ordered process, it starts very early during macronuclear development and has only finished immediately before DNA fragmentation takes place. It occurs in distinct steps and the IES are eliminated in a specific order, where a defined IES is only removed after complete elimination of other IES. Transfection experiments clearly demonstrate that the structure of the IES itself is not sufficient for its correct excision but other cis-acting sequences or additional structural requirements are needed for IES elimination.

摘要

在寡毛纲纤毛虫莱氏拟尾柱虫大核发育过程中，对一组大核前体DNA序列中的内部消除序列（IES）消除情况进行了分析。结果表明，IES消除是一个高度有序的过程，它在大核发育早期就开始了，并且仅在DNA片段化发生之前才完成。它以不同的步骤发生，IES按特定顺序被消除，其中一个特定的IES只有在其他IES完全消除后才会被去除。转染实验清楚地表明，IES自身的结构不足以实现其正确切除，IES消除还需要其他顺式作用序列或额外的结构要求。