Stender I M, Wulf H C
Department of Dermatology, National University Hospital, Rigshospitalet, Copenhagen, Denmark.
Br J Dermatol. 1996 Sep;135(3):454-6.
Three patients with cheilitis were successfully treated by photodynamic therapy using the topical application of 5-aminolevulinic acid (ALA), followed by irradiation with incoherent visible light. The three patients had had, for several years, disabling lesions on the lower lip, and histopathological examination showed dysplastic lesions without signs of carcinoma. Conventional treatments were ineffective. During photodynamic therapy, all patients reported a burning sensation when irradiated at the ALA treated area, diminishing immediately after removal of the light source, and vanishing within 4 days after treatment. Superficial peeling began 4 days after treatment, and lasted some months. Follow-up, after 6 and 12 months, did not reveal any sign of recurrence.
三名唇炎患者通过外用5-氨基酮戊酸（ALA）后用非相干可见光照射的光动力疗法成功治愈。这三名患者下唇出现致残性病变已有数年，组织病理学检查显示为发育异常病变，无癌变迹象。传统治疗方法无效。在光动力治疗期间，所有患者在ALA治疗区域照射时均报告有烧灼感，光源移除后立即减轻，并在治疗后4天内消失。治疗后4天开始出现浅表脱皮，持续数月。6个月和12个月后的随访未发现任何复发迹象。
