Kubota T, Tawara A, Hata Y, Khalil A, Inomata H
Department of Ophthalmology, Kyushu University, Fukuoka, Japan.
Br J Ophthalmol. 1996 Aug;80(8):750-4. doi: 10.1136/bjo.80.8.750.
AIMS/BACKGROUND: To investigate histological changes in the trabecular meshwork in eyes with neovascular glaucoma.
Light and electron microscopic studies were carried out on the trabecular meshwork of three enucleated eyes with neovascular glaucoma. The presence and distribution of factor VIII in the trabecular meshwork was assessed using the ABC method.
Peripheral anterior synechiae covering the trabecular meshwork were detected in two eyes, which would explain the rise in intraocular pressure. In the third the angle was not completely closed by peripheral anterior synechiae. The spaces between the trabecular beams were lined by a single layer of vascular endothelium, and were filled with red blood cells in this patient. Factor VIII was positively stained in the endothelial cells, lining both these spaces and Schlemm's canal. A basal lamina and microfibrils were detected just beneath the newly formed vascular endothelial cells.
The neovascular tissue found in the trabecular spaces might be one of the factors responsible for intraocular pressure elevation in eyes with neovascular glaucoma.
目的/背景：研究新生血管性青光眼患者小梁网的组织学变化。
对三只摘除眼球的新生血管性青光眼患者的小梁网进行光镜和电镜研究。采用ABC法评估小梁网中因子VIII的存在及分布。
两只眼中发现覆盖小梁网的周边前粘连，这可以解释眼压升高的原因。在第三只眼中，周边前粘连未完全封闭房角。小梁束之间的间隙由单层血管内皮细胞衬里，且该患者的间隙中充满红细胞。因子VIII在内皮细胞中呈阳性染色，这些间隙和施莱姆管的内皮细胞均如此。在新形成的血管内皮细胞下方检测到基底膜和微原纤维。
小梁间隙中发现的新生血管组织可能是新生血管性青光眼患者眼压升高的原因之一。
