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5-羟色胺1A受体激动剂8-OH-DPAT和5-羟色胺2A/2C激动剂DOI对脊髓损伤大鼠单突触传递的影响。

Effects of 8-OH-DPAT, a 5-HT1A receptor agonist, and DOI, a 5-HT2A/2C agonist, on monosynaptic transmission in spinalized rats.

作者信息

Hasegawa Y, Ono H

机构信息

Department of Pharmacy, Branch Hospital, Faculty of Medicine, University of Tokyo, Japan.

出版信息

Brain Res. 1996 Oct 28;738(1):158-61. doi: 10.1016/0006-8993(96)00991-2.

DOI:10.1016/0006-8993(96)00991-2
PMID:8949941
Abstract

We investigated the effect of 5-HT1A receptor agonist (-/+)-8-hydroxy-2-(di-N-propylamino)tetraline (8-OH-DPAT) and the 5-HT2A/2C receptor agonist (-/+)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on monosynaptic transmission in spinalized rats. 8-OH-DPAT significantly inhibited the excitation of alpha-motoneurons evoked by monosynaptic transmission without a direct effect on alpha-motoneuron excitation. DOI potentiated the excitation of alpha-motoneurons by both direct stimulation and monosynaptic transmission. These results indicate that activation of 5-HT1A receptors inhibits monosynaptic transmission, whereas activation of 5-HT2A/2C receptors enhances it.

摘要

我们研究了5-羟色胺1A受体激动剂（±）-8-羟基-2-（二-N-丙基氨基）四氢萘（8-OH-DPAT）和5-羟色胺2A/2C受体激动剂（±）-1-（2,5-二甲氧基-4-碘苯基）-2-氨基丙烷（DOI）对脊髓损伤大鼠单突触传递的影响。8-OH-DPAT显著抑制单突触传递诱发的α运动神经元兴奋，而对α运动神经元兴奋无直接影响。DOI通过直接刺激和单突触传递增强α运动神经元的兴奋。这些结果表明，5-羟色胺1A受体的激活抑制单突触传递，而5-羟色胺2A/2C受体的激活则增强单突触传递。

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