Egger N G, Goeger D E, Anderson K E
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston 77555-1109, USA.
Chem Biol Interact. 1996 Oct 21;102(2):69-78. doi: 10.1016/s0009-2797(96)03732-5.
Porphyrins and related compounds are useful in photodynamic therapy but can cause cutaneous photosensitivity. We determined whether chloroquine, which is effective in treating porphyria cutanea tarda, would mobilize an administered porphyrin from tissues and enhance its excretion. Hematoporphyrin with and without chloroquine was administered to chick embryos, mice, and rats. Tissue and plasma porphyrin levels were markedly increased after hematoporphyrin dosing. Porphyrin concentrations in liver, spleen, and kidney were not significantly affected by chloroquine. Total urinary and fecal porphyrin excretion in rats treated with hematoporphyrin (50 mg/kg, i.p.) was not influenced by chloroquine treatment (100 mg/kg, s.c.). Excretion of heptacarboxylporphyrin, normally a minor fraction of urinary porphyrins, was significantly increased in chloroquine-treated rats. These results suggest that chloroquine is unlikely to be useful after photodynamic therapy for mobilizing exogenous porphyrins from tissues such as liver, spleen, and kidney. Increased urinary excretion of heptacarboxylporphyrin may contribute to the beneficial effect of chloroquine in porphyria cutanea tarda.
卟啉及相关化合物在光动力疗法中很有用，但会引起皮肤光敏感性。我们研究了对迟发性皮肤卟啉症有效的氯喹是否能促使给药的卟啉从组织中释放出来并增加其排泄。给鸡胚、小鼠和大鼠分别注射含氯喹和不含氯喹的血卟啉。注射血卟啉后，组织和血浆中的卟啉水平显著升高。氯喹对肝脏、脾脏和肾脏中的卟啉浓度没有显著影响。用氯喹（100mg/kg，皮下注射）处理的大鼠，其血卟啉（50mg/kg，腹腔注射）处理后的总尿卟啉和粪卟啉排泄不受影响。在氯喹处理的大鼠中，通常占尿卟啉一小部分的七羧基卟啉的排泄显著增加。这些结果表明，光动力疗法后氯喹不太可能用于促使肝脏、脾脏和肾脏等组织中的外源性卟啉释放出来。七羧基卟啉尿排泄增加可能是氯喹对迟发性皮肤卟啉症有益作用的原因。
