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A subclone (5C6) of the human mast cell line HMC-1 represents a more differentiated phenotype than the original cell line.

作者信息

Weber S, Babina M, Krüger-Krasagakes S, Grützkau A, Henz B M

机构信息

Department of Dermatology, Virchow-Klinikum, Humboldt-Universität zu Berlin, Germany.

出版信息

Arch Dermatol Res. 1996 Nov;288(12):778-82. doi: 10.1007/BF02505297.

DOI:10.1007/BF02505297
PMID:8950460
Abstract
摘要

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1
A subclone (5C6) of the human mast cell line HMC-1 represents a more differentiated phenotype than the original cell line.人肥大细胞系HMC-1的一个亚克隆(5C6)比原始细胞系表现出更分化的表型。
Arch Dermatol Res. 1996 Nov;288(12):778-82. doi: 10.1007/BF02505297.
2
GM-CSF downmodulates c-kit, Fc(epsilon)RI(alpha) and GM-CSF receptor expression as well as histamine and tryptase levels in cultured human mast cells.粒细胞-巨噬细胞集落刺激因子可下调培养的人肥大细胞中c-kit、Fc(ε)RI(α)和粒细胞-巨噬细胞集落刺激因子受体的表达,以及组胺和类胰蛋白酶水平。
Arch Dermatol Res. 2001 May;293(5):249-58. doi: 10.1007/s004030100225.
3
Regulation of mast cell characteristics by cytokines: divergent effects of interleukin-4 on immature mast cell lines versus mature human skin mast cells.细胞因子对肥大细胞特性的调控:白细胞介素-4对未成熟肥大细胞系与成熟人皮肤肥大细胞的不同作用
Arch Dermatol Res. 2004 Aug;296(3):134-8. doi: 10.1007/s00403-004-0486-z. Epub 2004 Jul 30.
4
Phenotypic characterization of the human mast-cell line HMC-1.人肥大细胞系HMC-1的表型特征
Scand J Immunol. 1994 May;39(5):489-98. doi: 10.1111/j.1365-3083.1994.tb03404.x.
5
Mast cell lines HMC-1 and LAD2 in comparison with mature human skin mast cells--drastically reduced levels of tryptase and chymase in mast cell lines.肥大细胞系 HMC-1 和 LAD2 与成熟的人类皮肤肥大细胞比较——肥大细胞系中类胰蛋白酶和糜蛋白酶水平明显降低。
Exp Dermatol. 2010 Sep;19(9):845-7. doi: 10.1111/j.1600-0625.2010.01103.x. Epub 2010 Jun 2.
6
Chronically KIT-stimulated clonally-derived human mast cells show heterogeneity in different tissue microenvironments.长期受KIT刺激的克隆来源的人肥大细胞在不同组织微环境中表现出异质性。
J Invest Dermatol. 1997 May;108(5):792-6. doi: 10.1111/1523-1747.ep12292240.
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Reversible expression of tryptases in continuous L138.8A mast cells.色氨酸酶在连续传代的L138.8A肥大细胞中的可逆性表达。
Eur J Immunol. 2000 Oct;30(10):2954-61. doi: 10.1002/1521-4141(200010)30:10<2954::AID-IMMU2954>3.0.CO;2-S.
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Phenotypic evaluation of cultured human mast and basophilic cells and of normal human skin mast cells.培养的人肥大细胞和嗜碱性粒细胞以及正常人皮肤肥大细胞的表型评估。
Arch Dermatol Res. 1994;286(7):380-5. doi: 10.1007/BF00371797.
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GM-CSF downregulates expression of tryptase, Fc epsilon RI and histamine in HMC-1 mast cells.粒细胞-巨噬细胞集落刺激因子(GM-CSF)下调HMC-1肥大细胞中类胰蛋白酶、FcεRI和组胺的表达。
Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):284-6. doi: 10.1159/000237574.
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Human skin-derived mast cells can proliferate while retaining their characteristic functional and protease phenotypes.人皮肤来源的肥大细胞能够增殖,同时保持其特征性的功能和蛋白酶表型。
Blood. 2001 Apr 1;97(7):2045-52. doi: 10.1182/blood.v97.7.2045.

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The Inhibitory Effects of Low-Dose Ionizing Radiation in IgE-Mediated Allergic Responses.低剂量电离辐射对IgE介导的过敏反应的抑制作用。
PLoS One. 2015 Aug 28;10(8):e0136394. doi: 10.1371/journal.pone.0136394. eCollection 2015.
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Autophagy enhances bacterial clearance during P. aeruginosa lung infection.自噬增强铜绿假单胞菌肺部感染时的细菌清除。

本文引用的文献

1
The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression.人类肥大细胞糜蛋白酶基因(CMA1):定位于组织蛋白酶G/颗粒酶基因簇并呈谱系限制性表达。
Genomics. 1993 Mar;15(3):614-20. doi: 10.1006/geno.1993.1115.
2
Tumor necrosis factor alpha and interleukin-1 beta mRNA expression in HMC-1 cells: differential regulation of gene product expression by recombinant interleukin-4.HMC-1细胞中肿瘤坏死因子α和白细胞介素-1β mRNA的表达:重组白细胞介素-4对基因产物表达的差异调节
Exp Hematol. 1993 Aug;21(9):1271-5.
3
Phenotypic characterization of the human mast-cell line HMC-1.
PLoS One. 2013 Aug 28;8(8):e72263. doi: 10.1371/journal.pone.0072263. eCollection 2013.
4
Human mast cells (HMC-1 5C6) enhance interleukin-6 production by quiescent and lipopolysaccharide-stimulated human coronary artery endothelial cells.人肥大细胞(HMC-1 5C6)增强静止和脂多糖刺激的人冠状动脉内皮细胞产生白细胞介素-6。
Mediators Inflamm. 2012;2012:274347. doi: 10.1155/2012/274347. Epub 2012 Jan 26.
5
Selective early production of CCL20, or macrophage inflammatory protein 3alpha, by human mast cells in response to Pseudomonas aeruginosa.人肥大细胞对铜绿假单胞菌的反应中CCL20(即巨噬细胞炎性蛋白3α)的选择性早期产生
Infect Immun. 2003 Jan;71(1):365-73. doi: 10.1128/IAI.71.1.365-373.2003.
6
Comparative cytokine gene expression: regulation and release by human mast cells.细胞因子基因表达比较:人类肥大细胞的调控与释放
Immunology. 1998 Feb;93(2):289-95. doi: 10.1046/j.1365-2567.1998.00425.x.
人肥大细胞系HMC-1的表型特征
Scand J Immunol. 1994 May;39(5):489-98. doi: 10.1111/j.1365-3083.1994.tb03404.x.
4
Expression of multiple chemokine genes by a human mast cell leukemia.人肥大细胞白血病中多种趋化因子基因的表达
J Biol Chem. 1994 May 13;269(19):13893-8.
5
Monoclonal antibodies to leucosialin (CD43) induce homotypic aggregation of the human mast cell line HMC-1: characterization of leucosialin on HMC-1 cells.抗白细胞唾液酸蛋白(CD43)单克隆抗体诱导人肥大细胞系HMC-1的同型聚集:HMC-1细胞上白细胞唾液酸蛋白的特性
Immunology. 1994 Aug;82(4):638-44.
6
IL-4 enhances IL-3 and IL-8 gene expression in a human leukemic mast cell line.白细胞介素-4增强人白血病肥大细胞系中白细胞介素-3和白细胞介素-8的基因表达。
Immunology. 1995 Mar;84(3):410-5.
7
Effects of interleukin (IL)-13 on immediate-early response gene expression, phenotype and differentiation of human mast cells. Comparison with IL-4.白细胞介素(IL)-13对人肥大细胞即刻早期反应基因表达、表型及分化的影响。与IL-4的比较。
Eur J Immunol. 1995 Mar;25(3):870-3. doi: 10.1002/eji.1830250337.
8
Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product.在人肥大细胞白血病细胞系中鉴定原癌基因c-kit编码序列中的突变,该突变导致c-kit产物的配体非依赖性激活。
J Clin Invest. 1993 Oct;92(4):1736-44. doi: 10.1172/JCI116761.
9
Induction of human IgE synthesis in B cells by mast cells and basophils.肥大细胞和嗜碱性粒细胞诱导B细胞合成人IgE
Nature. 1993 Sep 23;365(6444):340-3. doi: 10.1038/365340a0.
10
Characterization of LDL and VLDL binding sites on human basophils and mast cells.人嗜碱性粒细胞和肥大细胞上低密度脂蛋白(LDL)和极低密度脂蛋白(VLDL)结合位点的特征分析。
Arterioscler Thromb Vasc Biol. 1995 Jan;15(1):17-26. doi: 10.1161/01.atv.15.1.17.