Jackson S P, Schoenwaelder S M, Yuan Y, Salem H H, Cooray P
Department of Medicine, Monash Medical School, Box Hill Hospital, Victoria, Australia.
Thromb Haemost. 1996 Nov;76(5):640-50.
There is now a large and rapidly growing body of information on the different types of non-receptor tyrosine kinases and phosphatases present within platelets. These enzymes appear to play a critical role in co-ordinating, integrating and amplifying signals from multiple cell surface receptors. Despite considerable progress in this area of research over the last decade, a coherent understanding of how these enzymes fit into the complex communication networks of platelets remains elusive. The challenge ahead will be to define the molecular interactions and hierarchies between tyrosine kinases, phosphatases and other platelet signalling enzymes, and to pinpoint the key phosphorylation reactions required for the induction of specific platelet responses.
目前，关于血小板中存在的不同类型非受体酪氨酸激酶和磷酸酶的信息大量涌现且迅速增加。这些酶似乎在协调、整合和放大来自多个细胞表面受体的信号方面发挥着关键作用。尽管在过去十年里该研究领域取得了显著进展，但对于这些酶如何融入血小板复杂的通讯网络，仍缺乏连贯的理解。未来的挑战将是确定酪氨酸激酶、磷酸酶和其他血小板信号酶之间的分子相互作用和层级关系，并找出诱导特定血小板反应所需的关键磷酸化反应。
