Sanderson P L, Fraser R D
Royal Adelaide Hospital, South Australia.
J Bone Joint Surg Br. 1996 Nov;78(6):951-4. doi: 10.1302/0301-620x78b6.1291.
Degenerative spondylolisthesis is most common at the L4/L5 level and in women. There are several possible reasons for its predilection at this site, but there is no satisfactory explanation for the predominance in women. We considered that pregnancy was a possible influence. We reviewed the records and radiographs of 949 women and 120 men aged 50 years and over who had attended a spinal surgeon for low back pain over a five-year period. We found that women who had borne children had a significantly higher incidence of degenerative spondylolisthesis than nulliparous women (28% v 16.7%; p=0.043). The men had a 7.5% incidence, significantly less than nulliparous women (p = 0.031). Our results suggest that pregnancy is an important factor in the aetiology of degenerative spondylolisthesis.
退变性腰椎滑脱最常见于L4/L5节段，且多见于女性。其在该部位好发有多种可能原因，但女性发病率更高尚无令人满意的解释。我们认为怀孕可能是一个影响因素。我们回顾了949名50岁及以上女性和120名50岁及以上男性在五年期间因腰背痛就诊于脊柱外科医生的病历和X光片。我们发现，已生育女性退变性腰椎滑脱的发病率显著高于未生育女性（28%对16.7%；p = 0.043）。男性发病率为7.5%，显著低于未生育女性（p = 0.031）。我们的结果表明，怀孕是退变性腰椎滑脱病因中的一个重要因素。
