Hutchings A D, Routledge P A
Department of Pharmacology and Therapeutics, University of Wales College of Medicine, Cardiff, UK.
Br J Clin Pharmacol. 1996 Nov;42(5):635-7. doi: 10.1111/j.1365-2125.1996.tb00121.x.
A comparison was made between the results of acetylator phenotyping by determination of the acetylisoniazid to isoniazid (AcINH/INH) concentration ratio in plasma and in saliva 3 h after oral administration of isoniazid (200mg). In the 154 subjects studied, 68 (44%) were fast acetylators (AcINH/INH ratio > 1.5) using the plasma ratio. In all subjects the saliva AcINH/INH ratio was also > 1.5. Eighty-five of the eighty-six remaining subjects had saliva and plasma AcINH/INH ratios < 1.5 in the 3 h sample. Thus, with one exception there was complete agreement between the acetylator status determined by measurement of saliva or plasma AcINH/INH ratio in a single 3 h sample. Saliva measurement may provide a simple non-invasive alternative to plasma collection in assessing acetylator status.
通过测定口服异烟肼（200mg）3小时后血浆和唾液中乙酰异烟肼与异烟肼（AcINH/INH）的浓度比，对乙酰化表型的结果进行了比较。在研究的154名受试者中，以血浆比值计算，68名（44%）为快乙酰化者（AcINH/INH比值>1.5）。所有受试者的唾液AcINH/INH比值也>1.5。其余86名受试者中的85名在3小时样本中的唾液和血浆AcINH/INH比值<1.5。因此，除了一个例外，通过在单一3小时样本中测量唾液或血浆AcINH/INH比值所确定的乙酰化状态完全一致。在评估乙酰化状态时，唾液测量可能为采集血浆提供一种简单的非侵入性替代方法。
