Arai Y, Takeuchi H, Okada Y, Tomoyoshi T
Department of Urology, Shiga University of Medical Science.
Hinyokika Kiyo. 1996 Oct;42(10):729-34.
We examined the relationship between struvite stone formation and Ureaplasma urealyticum in male Wister rats by inoculating U. urealyticum and implanting a zinc disc into the bladder surgically. Cultures of U. urealyticum and pH measurements in urine obtained by forced urination were done on days 2 and 6 after operation. Half of the rats were killed 7 days after the operation and the remaining half 14 days after the operation. A total of 46 rats, consisting of 10 rats in the control group and 36 rats inoculated with U. urealyticum, were studied. U. urealyticum was weakly virulent, because it was not detected in the urine culture on day 2 in 10 of the 36 rats inoculated with the organism, and showed a tendency towards spontaneous elimination in the other rats. Urinary pH was elevated slightly by the presence of U. urealyticum. Struvite stones were formed in 52% of the rats by the inoculation on of U. urealyticum, and 69% and 71% of the positive rats in urine culture for U. urealyticum on day 2 and day 6 respectively. The stones tended to be larger the longer U. urealyticum was detected in urine. U. urealyticum may play a role in struvite stone formation, but not a major role.
我们通过手术将解脲脲原体接种到雄性Wistar大鼠体内并在膀胱中植入锌盘，研究了解脲脲原体与鸟粪石形成之间的关系。在术后第2天和第6天进行解脲脲原体培养以及通过强制排尿获取尿液进行pH测量。一半大鼠在术后7天处死，另一半在术后14天处死。总共研究了46只大鼠，其中对照组10只，接种解脲脲原体的大鼠36只。解脲脲原体毒力较弱，因为在接种该病原体的36只大鼠中，有10只在术后第2天的尿液培养中未检测到，并且在其他大鼠中显示出自然清除的趋势。解脲脲原体的存在使尿液pH略有升高。接种解脲脲原体的大鼠中有52%形成了鸟粪石，在术后第2天和解脲脲原体尿液培养呈阳性的大鼠中分别有69%和71%在术后第6天形成了鸟粪石。在尿液中检测到解脲脲原体的时间越长，结石往往越大。解脲脲原体可能在鸟粪石形成中起作用，但不是主要作用。
