Wu W N, Beal J L, Leu R P, Doskotch R W
Lloydia. 1977 May-Jun;40(3):281-9.
A study of the alkaloids of the roots of Thalictrum longistylum DC. resulted in the isolation of 12 alkaloids plus an artifact, 8-trichloromethyldihydroberberine. The 12 alkaloids were berberine, columbamine, jatrorrhizine, magnoflorine, methothalistyline, N-desmethylthalistyline, oxyberberine, palmatine, thalibrine, thalifendine, thaliglucinone, and thalistyline. Of these alkaloids, methothalistyline, N-desmethylthalistyline, and thalistyline are new compounds and with thaliglucinone possess hypotensive activity in dogs and rabbits. Methothalistyline, N-demethylthalistyline, thalistyline, and thalibrine were found to be active against Staphylococcus aureus and Mycobacterium smegmatis with with thalistyline being most active (50 microgram/ml).
对长柱唐松草根生物碱的研究，分离出了12种生物碱以及一种人工产物8 - 三氯甲基二氢小檗碱。这12种生物碱分别是小檗碱、黄连碱、药根碱、木兰碱、甲硫唐松草碱、N - 去甲基唐松草碱、氧化小檗碱、巴马汀、唐松草里定、唐松草芬定、唐松草素酮和唐松草碱。在这些生物碱中，甲硫唐松草碱、N - 去甲基唐松草碱和唐松草碱是新化合物，且与唐松草素酮在犬和兔身上具有降压活性。发现甲硫唐松草碱、N - 去甲基唐松草碱、唐松草碱和唐松草里定对金黄色葡萄球菌和耻垢分枝杆菌有活性，其中唐松草碱活性最强（50微克/毫升）。
