Wu W N, Beal J L, Doskotch R W
Lloydia. 1977 Sep-Oct;40(5):508-14.
Sixteen alkaloids were characterized from Thalictrum revolutum DC., namely; thalidasine, O-methylthalmethine, O-methylthalicberine, thalrugosaminine, thalicarpine, thalmelatine, pennsylvanine, palmatine, berberine, thalifendine, columbamine, jatrorrhizine, deoxythalidastine, thalphenine and magnoflorine. The structure of thairugosaminine (1) a bisbenzylisoquinoline type which was previously proposed on partial data was completely established, including the absolute configuration as S,S. Thalphenine, thalidasine, O-methylthalicberine, thalicarpine, thalrugosaminine and thaliglucinone were found to possess hypotensive activity in rabbits. Thalrugosaminine, thalicarpine, thalmelatine, O-methylthalmethine, pennsylvanine and thalphenine were found to be active against Mycobacterium smegmatis.
从唐松草（Thalictrum revolutum DC.）中鉴定出16种生物碱，即：唐松星碱、O - 甲基唐松甲碱、O - 甲基唐松里丁碱、唐松草格萨明宁、唐松草卡品碱、唐松草美拉汀、宾夕法尼亚唐松草碱、巴马汀、小檗碱、唐松草芬定、黄连碱、药根碱、脱氧唐松星定、唐松草宁碱和木兰碱。之前根据部分数据推测为双苄基异喹啉型的唐松草格萨明宁（1）的结构得以完全确定，包括其绝对构型为S,S。发现唐松草宁碱、唐松星碱、O - 甲基唐松里丁碱、唐松草卡品碱、唐松草格萨明宁和唐松草素酮对家兔具有降压活性。发现唐松草格萨明宁、唐松草卡品碱、唐松草美拉汀、O - 甲基唐松甲碱、宾夕法尼亚唐松草碱和唐松草宁碱对耻垢分枝杆菌有活性。
