Wu W N, Beal J L, Mitscher L A, Salman K N, Patil P
Lloydia. 1976 Jul-Aug;39(4):204-12.
Sixteen alkaloids, namely homoaromoline, obaberine, O-methyl-thalicberine, oxyberberine, thalidasine, thaliglucinone, thalrugosine, obamegine, oxyacanthine, berberine, columbamine, jatrorrhizine, magnoflorine, palmatine, thalifendine and base A chloride, plus the artifact, 8-trichloromethyldihydroberberine, were isolated from the alkaloid fraction of the roots of Thalictrum lucidum L. Of these, obamegine, thalrugosine, O-methylthalicberine, thaliglucinone, obaberine and homoaromoline were found to possess hypotensive activity in normotensive dogs. Thalidasine, homoaromoline, thalrugosine, thaliglucinone, obamegine, jatrorrhizine, and columbamine were found to possess antimicrobial activity against Mycobacterium smegmatis at a concentration of 100 mug/ml or less.
从唐松草根的生物碱部分分离出16种生物碱，即高阿罗莫林、奥巴贝林、O - 甲基 - thalicberine、氧化小檗碱、唐松草辛、唐松草素酮、唐松草鲁辛、奥巴美宁、刺檗碱、小檗碱、黄连碱、药根碱、木兰碱、巴马汀、唐松草定和碱A氯化物，以及人工产物8 - 三氯甲基二氢小檗碱。其中，发现奥巴美宁、唐松草鲁辛、O - 甲基thalicberine、唐松草素酮、奥巴贝林和高阿罗莫林在正常血压犬中具有降压活性。发现唐松草辛、高阿罗莫林、唐松草鲁辛、唐松草素酮、奥巴美宁、药根碱和黄连碱在浓度为100μg/ml或更低时对耻垢分枝杆菌具有抗菌活性。
