Endoh M, Matsuda A
Department of Anesthesia, Kantoh Rosai Hospital, Kawasaki.
Masui. 1996 Nov;45(11):1396-9.
We compared the efficacy of epidurally administered buprenorphine (0.2 mg) after combined spinal-epidural anesthesia (CSE group) and that after general anesthesia combined with epidural anesthesia (EPI + GEN group). Postoperatively epidural buprenorphine was administered for initial pain relief significantly later in CSE group than in EPI + GEN group. The duration of pain relief with epidural buprenorphine was similar in both groups (about 11 hours). The time period until postoperative first walk and the number of pain relief medication were also similar in both groups. We had the impression that the onset of pain relief was faster in CSE group, probably because there might be flux of buprenorphine through a dural hole just after epidural administration.
我们比较了腰麻-硬膜外联合麻醉（CSE组）和全身麻醉联合硬膜外麻醉（EPI + GEN组）后硬膜外给予丁丙诺啡（0.2毫克）的效果。术后硬膜外给予丁丙诺啡用于初始镇痛时，CSE组明显晚于EPI + GEN组。两组硬膜外丁丙诺啡的镇痛持续时间相似（约11小时）。两组术后首次行走的时间和镇痛药物的使用次数也相似。我们感觉CSE组的镇痛起效更快，可能是因为硬膜外给药后丁丙诺啡可能通过硬脊膜孔道流动。
