Takamatsu F, Taoda M, Uchihashi Y, Satoh T
Department of Anesthesiology, National Defense Medical College, Tokorozawa.
Masui. 1996 Nov;45(11):1406-9.
An 81-year-old man was scheduled for cervical lymph node biopsy. His laboratory data were within normal ranges. After induction of anesthesia with thiopental 175 mg and succinylcholine chloride (SCC) 40 mg, moderate masseter spasm was observed. Anesthesia was maintained with nitrous oxide, oxygen and sevoflurane. After the operation he had severe muscle pain and CK was elevated up to 81,400IU.l-1. The body temperature was not elevated above 37.2 degrees C during and after the operation. The skinned fiber examination, performed one month later, showed his calcium-induced-calcium-release (CICR) to be within normal ranges. We diagnosed him as rhabdomyolysis induced by coadministration of SCC and sevoflurane, especially SCC. We concluded that even in an elderly man, SCC should be administered cautiously.
一名81岁男性计划接受颈部淋巴结活检。他的实验室检查数据均在正常范围内。静脉注射175mg硫喷妥钠和40mg氯化琥珀酰胆碱诱导麻醉后,观察到中度咬肌痉挛。采用氧化亚氮、氧气和七氟醚维持麻醉。术后他出现严重肌肉疼痛,肌酸激酶(CK)升高至81400IU.l-1。术中及术后体温未超过37.2℃。一个月后进行的皮肤纤维检查显示,他的钙诱导钙释放(CICR)在正常范围内。我们诊断他为氯化琥珀酰胆碱与七氟醚联合使用,尤其是氯化琥珀酰胆碱导致的横纹肌溶解。我们得出结论,即使是老年男性,使用氯化琥珀酰胆碱也应谨慎。