Kitamura N, Yamaguchi M, Shimabukuro K, Miyasaka M, Nakano H, Kumada K
Department of Surgery, Showa University Fujigaoka Hospital, Yokohama, Japan.
Eur Surg Res. 1996;28(6):428-35. doi: 10.1159/000129487.
Since heparin-like glycosaminoglycans (GAGs) have been reported to possess anti-inflammatory effects, we tested effects of heparin-like GAGs on cell adhesion between endothelial cells (ECs) and leukocytes. Effects of heparin-like GAGs on adhesion molecule expression and leukocyte adhesion were analyzed using cultured human umbilical vein ECs stimulated by endotoxin. Expression of adhesion molecules on ECs was unchanged, but adherence of leukocytes to ECs was significantly reduced by heparin-like GAGs under nonstatic conditions. These results suggest that heparin-like GAGs may act as anti-inflammatory agents partly by inhibition of leukocyte adherence to stimulated ECs under nonstatic conditions and may prevent critical conditions caused by endotoxin.
由于据报道类肝素糖胺聚糖（GAGs）具有抗炎作用，我们测试了类肝素GAGs对内皮细胞（ECs）与白细胞之间细胞黏附的影响。使用经内毒素刺激的培养人脐静脉ECs分析类肝素GAGs对黏附分子表达和白细胞黏附的影响。ECs上黏附分子的表达没有变化，但在非静态条件下，类肝素GAGs显著降低了白细胞与ECs的黏附。这些结果表明，类肝素GAGs可能部分通过在非静态条件下抑制白细胞与受刺激ECs的黏附而发挥抗炎剂的作用，并可能预防由内毒素引起的危急情况。
