Husband A J, Gleeson M
Department of Veterinary Pathology, University of Sydney, New South Wales, Australia.
Brain Behav Immun. 1996 Sep;10(3):188-204. doi: 10.1006/brbi.1996.0018.
Since mucosal surfaces represent the interface between the host and the environment and are the most common portal of pathogen entry, early development of functional mucosal immune defense is essential for survival. The development of mucosal immune function is profoundly influenced by maternal, environmental, and behavioral factors and although the impact of these is greatest during the prenatal and immediately postnatal periods, their influence extends beyond this period and patterns of development in postnatal life determine many of the immune outcomes in later life. This review will correlate information regarding age-related changes occurring in mucosal-associated lymphoid tissue from a variety of animal models and in humans and will explore how the interactions which exist between the immune and neuroendocrine systems orchestrate these effects. In particular the role of prenatal and postnatal stressors, feeding patterns, nutritional factors, infections, and exposure to allergens and toxins are addressed. A clear understanding of the way in which these factors interact to influence development and control of mucosal immune function will assist in the design of neonatal vaccination and disease management strategies.
由于黏膜表面是宿主与环境的界面，也是病原体最常见的进入门户，因此功能性黏膜免疫防御的早期发育对生存至关重要。黏膜免疫功能的发育受到母体、环境和行为因素的深刻影响，尽管这些因素在产前和产后即刻的影响最大，但其影响超出了这个时期，出生后生活的发育模式决定了晚年的许多免疫结果。本综述将关联来自各种动物模型和人类的黏膜相关淋巴组织中发生的与年龄相关变化的信息，并将探讨免疫和神经内分泌系统之间存在的相互作用如何协调这些影响。特别讨论了产前和产后应激源、喂养模式、营养因素、感染以及接触过敏原和毒素的作用。清楚了解这些因素相互作用以影响黏膜免疫功能发育和控制的方式，将有助于设计新生儿疫苗接种和疾病管理策略。
