Schrott L M, Crnic L S
Department of Psychiatry, University of Colorado School of Medicine, Denver 80262, USA.
Brain Behav Immun. 1996 Sep;10(3):260-74. doi: 10.1006/brbi.1996.0023.
Behavioral changes often accompany the autoimmune disease systemic lupus erythematosus (SLE) in humans and animals. In a mouse model of SLE, the NZB x NZW F1 (B/W) hybrid, 12-week-old mice display more anxiety behavior, less activity, and less exploratory behavior than non-autoimmune female NZW mice. To determine whether these behaviors result from the autoimmune disease or genetic differences between B/W and NZW mice, they were assessed prior to and during disease emergence (6 and 12 weeks of age, respectively). B/W mice were less active at both ages, suggesting a genetic component to this behavioral difference. Anxiety behavior and exploratory behavior did not differ between B/W and NZW mice at 6 weeks; however, at 12 weeks B/W mice displayed more anxiety behavior and less exploratory behavior, indicating that these behaviors were related with the development of autoimmune disease. Prior experience with these tasks increased anxiety behavior in B/W but not NZW mice, suggesting that B/W mice may be more sensitive to anxiogenic experiences.
行为变化常伴随人类和动物的自身免疫性疾病系统性红斑狼疮（SLE）出现。在SLE的小鼠模型新西兰黑鼠与新西兰白鼠杂交一代（B/W）中，12周龄的小鼠比非自身免疫性的雌性新西兰白鼠表现出更多焦虑行为、更少活动及更少探索行为。为确定这些行为是由自身免疫性疾病还是B/W和新西兰白鼠之间的基因差异导致的，在疾病出现之前及期间（分别为6周龄和12周龄）对它们进行了评估。B/W小鼠在两个年龄阶段都活动较少，表明这种行为差异存在遗传因素。在6周龄时，B/W和新西兰白鼠之间的焦虑行为和探索行为没有差异；然而，在12周龄时，B/W小鼠表现出更多焦虑行为和更少探索行为，表明这些行为与自身免疫性疾病的发展有关。之前进行这些任务的经历增加了B/W小鼠的焦虑行为，但未增加新西兰白鼠的焦虑行为，这表明B/W小鼠可能对产生焦虑的经历更敏感。
