Leclercq-Meyer V, Considine R V, Sener A, Malaisse W J
Laboratory of Experimental Medicine, Brussels Free University, Brussels, B-1070, Belgium.
Biochem Biophys Res Commun. 1996 Dec 24;229(3):794-8. doi: 10.1006/bbrc.1996.1882.
It was recently speculated that leptin may exert a direct inhibitory effect upon insulin release from the pancreatic B-cell. This proposal meets, however, with two objections. First, although the message for leptin receptors is indeed detected in rat pancreatic islets, the short form of this receptor, for which no signalling function is known, represents the major species present in islet cells. Second, in the isolated perfused rat pancreas, leptin (1.0 nM) fails to affect the release of either insulin or glucagon.
最近有人推测，瘦素可能对胰腺β细胞释放胰岛素产生直接抑制作用。然而，这一观点存在两个问题。第一，尽管在大鼠胰岛中确实检测到了瘦素受体的信息，但这种受体的短形式在胰岛细胞中占主要部分，而其信号传导功能尚不清楚。第二，在离体灌注的大鼠胰腺中，瘦素（1.0 nM）不会影响胰岛素或胰高血糖素的释放。
