Denroche Heather C, Huynh Frank K, Kieffer Timothy J
Department of Cellular and Physiological Sciences, The Life Sciences Institute.
Department of Cellular and Physiological Sciences, The Life Sciences Institute ; Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.
J Diabetes Investig. 2012 Mar 28;3(2):115-29. doi: 10.1111/j.2040-1124.2012.00203.x.
The fat-derived hormone, leptin, is well known to regulate body weight. However, there is now substantial evidence that leptin also plays a primary role in the regulation of glucose homeostasis, independent of actions on food intake, energy expenditure or body weight. As such, leptin might have clinical utility in treating hyperglycemia, particularly in conditions of leptin deficiency, such as lipodystrophy and diabetes mellitus. The mechanisms through which leptin modulates glucose metabolism have not been fully elucidated. Leptin receptors are widely expressed in peripheral tissues, including the endocrine pancreas, liver, skeletal muscle and adipose, and both direct and indirect leptin action on these tissues contributes to the control of glucose homeostasis. Here we review the role of leptin in glucose homeostasis, along with our present understanding of the mechanisms involved. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2012.00203.x, 2012).
脂肪衍生激素瘦素以调节体重而闻名。然而，现在有大量证据表明，瘦素在葡萄糖稳态调节中也起主要作用，独立于对食物摄入、能量消耗或体重的影响。因此，瘦素在治疗高血糖方面可能具有临床应用价值，特别是在瘦素缺乏的情况下，如脂肪营养不良和糖尿病。瘦素调节葡萄糖代谢的机制尚未完全阐明。瘦素受体广泛表达于外周组织，包括内分泌胰腺、肝脏、骨骼肌和脂肪组织，瘦素对这些组织的直接和间接作用都有助于控制葡萄糖稳态。在此，我们综述瘦素在葡萄糖稳态中的作用，以及我们目前对所涉及机制的理解。（《糖尿病研究杂志》，doi: 10.1111/j.2040-1124.2012.00203.x，2012年）
