Nicolai T, Mutius E V
Universitätskinderklinik München, Germany.
Acta Paediatr. 1996 Nov;85(11):1295-9. doi: 10.1111/j.1651-2227.1996.tb13914.x.
All fourth-grade school children in Munich and the surrounding districts (age 9-11 years, n = 9403) were surveyed with a questionnaire, lung function testing and bronchial provocation. Croup was reported in 9.8%. In these children, lung function was decreased even after controlling for asthma and other confounding factors. Only recurrent croup had an increased prevalence in children with asthma. When a family history for asthma, maternal smoking and social status were included into a logistic multiple regression model, the odds ratio to develop asthma was 2.91 (confidence interval (CI) 2.19 - 3.86) for children with a history of croup, 2.60 (CI 1.93 - 3.51) for a family history for asthma and 8.60 (CI 4.99 - 14.80) for the combination of family history and croup. Asthma was diagnosed in 37.3% of children with croup and a positive family history.
对慕尼黑及周边地区所有四年级学童（9至11岁，n = 9403）进行了问卷调查、肺功能测试和支气管激发试验。报告显示哮吼发病率为9.8%。在这些儿童中，即使在控制哮喘和其他混杂因素后，肺功能仍有所下降。只有复发性哮吼在哮喘儿童中的患病率有所增加。当将哮喘家族史、母亲吸烟情况和社会地位纳入逻辑多元回归模型时，有哮吼病史的儿童患哮喘的比值比为2.91（置信区间（CI）2.19 - 3.86），有哮喘家族史的儿童为2.60（CI 1.93 - 3.51），有家族史和哮吼病史的儿童为8.60（CI 4.99 - 14.80）。在有哮吼病史且家族史呈阳性的儿童中，37.3%被诊断为哮喘。
