Zach M, Erben A, Olinsky A
Arch Dis Child. 1981 May;56(5):336-41. doi: 10.1136/adc.56.5.336.
One hundred and ten children were studied 9 years after each had been in hospital for croup. They were evaluated with a questionnaire, physical examination, allergy skin testing, pulmonary function tests, and a histamine inhalation challenge. Fifty-seven of them had recurrent episodes of croup, and 33 were defined as allergic. The association between allergy and recurrent croup was highly significant. Airways hyper-reactivity was found in 23 of them, and was associated with allergy and recurrent croup. The group of children with a history of recurrent croup could be distinguished from the group with one or two episodes by male predominance, onset of the disease at a younger age, familial predisposition, a significantly greater association with allergy and airways hyper-reactivity, slightly lower expiratory flow rates in pulmonary function tests, and a tendency towards the subsequent development of asthma.
对110名曾因哮吼住院的儿童进行了9年的随访研究。通过问卷调查、体格检查、过敏皮肤试验、肺功能测试和组胺吸入激发试验对他们进行了评估。其中57人有哮吼复发，33人被定义为过敏体质。过敏与哮吼复发之间的关联非常显著。其中23人存在气道高反应性，且与过敏和哮吼复发有关。有哮吼复发史的儿童组与有一两次发作的儿童组相比，具有男性居多、发病年龄较小、家族易感性、与过敏和气道高反应性的关联显著更强、肺功能测试中呼气流量略低以及随后有发展为哮喘的倾向等特点。
