Kasch K L, Klein D N
Psychology Department, State University of New York at Stony Brook 11794-2500, USA.
J Nerv Ment Dis. 1996 Nov;184(11):703-7. doi: 10.1097/00005053-199611000-00008.
The Epidemiologic Catchment Area community sample data were analyzed to determine whether there is a general tendency for subjects with two or more disorders to have an earlier age of onset of the index disorder than subjects with only one disorder. DSM-III axis I disorders and antisocial personality were each used as index disorders in separate logistic regressions. The results show that an earlier age of onset is associated with greater comorbidity in major depression, with a similar trend for alcoholism. Schizophrenia and the phobias, however, showed significant results in the opposite direction. Overall, the results argue for specific rather than general effects of age of onset on comorbidity.
对流行病学集水区社区样本数据进行分析，以确定患有两种或更多种疾病的受试者与仅患有一种疾病的受试者相比，是否普遍存在索引疾病发病年龄更早的倾向。在单独的逻辑回归分析中，分别将《精神疾病诊断与统计手册》第三版轴I障碍和反社会人格作为索引疾病。结果表明，在重度抑郁症中，发病年龄较早与更高的共病率相关，酗酒也有类似趋势。然而，精神分裂症和恐惧症的结果则相反。总体而言，结果表明发病年龄对共病的影响是特定的，而非普遍的。
