Migaldi M, Zunarelli E, Criscuolo M, Lauriola P, De Girolamo G, Barbolini G
Dipartimento di Scienze Morfologiche e Medico Legali, Università di Modena.
Pathologica. 1996 Aug;88(4):297-302.
This study was performed on 1710 lung epithelial malignant tumours, diagnosed in the biennia 1963/1964 (42 cases), 1973/ 1974 (293), 1983/1984 (637) and 1993/1994 (738). It was aimed at evaluating whether, over a time span that long, the distribution of the histopathological patterns could have changed. The neoplasms were classified according to the WHO criteria (1981). From our data, a striking increase becomes apparent for all histotypes. Squamous cell carcinoma holds the leading position both among males and females, even though its rate of increase tends to slow down among males. Analogous trend is observed for all the other histotypes but adenocarcinoma. Among females, the rate of increase continues to accelerate for all histotypes but large cell carcinoma. The male to female ratio is ranging from 2:6 for adenocarcinomas to 12:1 for squamous cell carcinomas. In conclusion, impressive changes seem to have occurred in the frequency of the different lung oncotypes over this time span, especially for adenocarcinoma (increasing trend) and large cell carcinoma (decreasing trend). It also seems worth underlying that the marked increase among females could make lung carcinoma the number one cause of cancer-related deaths in this sex.
本研究对1963/1964年（42例）、1973/1974年（293例）、1983/1984年（637例）和1993/1994年（738例）确诊的1710例肺上皮恶性肿瘤进行。其目的是评估在如此长的时间跨度内，组织病理学模式的分布是否发生了变化。肿瘤根据世界卫生组织标准（1981年）进行分类。从我们的数据来看，所有组织学类型均有显著增加。鳞状细胞癌在男性和女性中均占主导地位，尽管其在男性中的增长率趋于放缓。除腺癌外，所有其他组织学类型均观察到类似趋势。在女性中，除大细胞癌外，所有组织学类型的增长率均持续加速。腺癌的男女比例为2:6，鳞状细胞癌为12:1。总之，在这段时间跨度内，不同肺肿瘤类型的发生率似乎发生了显著变化，尤其是腺癌（呈上升趋势）和大细胞癌（呈下降趋势）。还值得强调的是，女性中的显著增加可能使肺癌成为该性别中与癌症相关死亡的首要原因。
