Walker R A, Lees E, Webb M B, Dearing S J
Breast Cancer Research Unit, University of Leicester, Glenfield Hospital, UK.
Br J Cancer. 1996 Dec;74(11):1796-800. doi: 10.1038/bjc.1996.632.
One hundred and sixty-three breast carcinomas occurring in women aged between 26 and 44 years were examined for pathological features, oestrogen and progesterone receptor status, proliferation as determined by Ki-67 labelling and the presence of c-erbB-2 and p53 protein, and were compared with a control group of carcinomas from women in the 50-67 years age group. Carcinomas occurring in women aged under 35 years had a significantly high incidence of being poorly differentiated and of having high proliferation rates. This group also had a significantly high incidence of p53 protein staining. Carcinomas in the under 30 years age group had a lower incidence of oestrogen and progesterone receptor positivity. No differences were found in c-erbB-2-positive staining between the groups. Infiltrating lobular carcinomas were only identified in women aged 40 years and over. There was a higher incidence of a family history in the 35-44 years age group (18%) than in the under 35 years age group (11%). Breast carcinomas occurring in women aged under 35 years are more aggressive. An important finding is the high incidence of p53 positivity, which may indicate genetic instability.
对163例年龄在26至44岁之间的女性乳腺癌患者进行了病理特征、雌激素和孕激素受体状态、通过Ki-67标记测定的增殖情况以及c-erbB-2和p53蛋白表达情况的检查，并与一组年龄在50至67岁之间的女性乳腺癌对照组进行了比较。35岁以下女性发生的乳腺癌中，低分化和高增殖率的发生率显著较高。该组中p53蛋白染色的发生率也显著较高。30岁以下年龄组的乳腺癌中，雌激素和孕激素受体阳性的发生率较低。两组之间c-erbB-2阳性染色未发现差异。浸润性小叶癌仅在40岁及以上的女性中发现。35至44岁年龄组（18%）的家族史发生率高于35岁以下年龄组（11%）。35岁以下女性发生的乳腺癌侵袭性更强。一个重要发现是p53阳性的高发生率，这可能表明基因不稳定。
