伴新发18号染色体短臂等臂染色体及前期再生障碍性贫血的微分化型急性髓细胞白血病的发生
Development of minimally differentiated acute myeloblastic leukemia with novel isochromosome 18p and antecedent aplastic anemia.
作者信息
Keung Y K, Cobos E, Morgan D, Tonk V
机构信息
Division of Oncology/Hematology, Texas Tech University Health Sciences Center, Lubbock 79430, USA.
出版信息
Cancer Genet Cytogenet. 1996 Nov;92(1):1-3. doi: 10.1016/s0165-4608(96)00171-9.
We describe a case of acute myeloblastic leukemia with a novel isochromosome 18, i(18)(p10), preceded by aplastic anemia for six months. The patient is a cotton grower chronically exposed to pesticides. The significance of this chromosomal abnormality is unknown. The possible relationship to the preceding history of aplastic anemia and occupational pesticide exposure is speculated on. The possible mechanism of the association of acute leukemia and aplastic anemia is discussed.
我们描述了一例急性髓细胞白血病患者，其具有一条新的18号等臂染色体，即i(18)(p10)，该患者之前有6个月的再生障碍性贫血病史。患者是一名长期接触农药的棉农。这种染色体异常的意义尚不清楚。推测了其与之前再生障碍性贫血病史及职业性农药接触之间可能的关系。讨论了急性白血病与再生障碍性贫血关联的可能机制。
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