Mizunuma H, Tsuchiya A, Ando Y, Kikuchi Y, Abe R
Department of Surgery II, Fukushima Medical College, Japan.
Eur J Surg. 1996 Nov;162(11):889-94.
To find out if there is any correlation between the DNA aneuploidy in gastric cancer that is invading the muscularis propria and survival.
Retrospective study.
Teaching hospital, Japan.
52 patients who underwent gastric resection for gastric cancer that was invading the muscularis propria, and for whom clinical follow-up data were available.
Flow cytometric measurement of DNA in paraffin-embedded tissue.
Correlation between survival and clinicopathological variables including ploidy.
22 (42%) of the cases were aneuploid and 30 (58%) were diploid. The lymph node status and DNA ploidy were the significant prognostic variables, but a multivariate analysis showed that only DNA ploidy was significant.
Nuclear DNA ploidy is an independent prognostic factor in gastric cancer that is invading the muscularis propria.
探究侵犯固有肌层的胃癌中DNA非整倍体与生存之间是否存在相关性。
回顾性研究。
日本教学医院。
52例行胃癌根治术且侵犯固有肌层、有临床随访数据的患者。
对石蜡包埋组织进行DNA流式细胞术检测。
生存与包括倍性在内的临床病理变量之间的相关性。
22例（42%）为非整倍体，30例（58%）为二倍体。淋巴结状态和DNA倍性是显著的预后变量，但多因素分析显示只有DNA倍性具有显著性。
核DNA倍性是侵犯固有肌层的胃癌的独立预后因素。
