Meyers K E, Strife C F, Witzleben C, Kaplan B S
Division of Nephrology, The Children's Hospital of Philadelphia, PA 19104, USA.
Am J Kidney Dis. 1996 Dec;28(6):804-10. doi: 10.1016/s0272-6386(96)90379-0.
Patients with membranoproliferative glomerulonephritis (MPGN) type III and a low serum C3 concentration tend to have evidence for a nephritic factor of the terminal complement pathway (Nft). Complement profiles were studied in three patients with MPGN type III and low serum C3 concentrations. Serum C3 concentrations were 52, 21, and 14 mg/dL (normal range, 83 to 177 mg/dL). Serum Clq, C2, C4, properdin, and C5 concentrations were normal in all patients, whereas two had a slight decrease of C7 or C8. This pattern of complement activation resembles that seen with MPGN type II in which a nephritic factor activates the amplification loop (NFa). We conclude that in patients with MPGN type III the previously reported profile/presence of Nft is not always found, at least in the chronic stage of the disease, despite a low C3 value.
III型膜增生性肾小球肾炎（MPGN）且血清C3浓度较低的患者往往有终末补体途径肾炎因子（Nft）的证据。对3例III型MPGN且血清C3浓度较低的患者的补体谱进行了研究。血清C3浓度分别为52、21和14mg/dL（正常范围为83至177mg/dL）。所有患者的血清Clq、C2、C4、备解素和C5浓度均正常，而其中2例患者的C7或C8略有下降。这种补体激活模式类似于II型MPGN中所见的模式，即肾炎因子激活放大环（NFa）。我们得出结论，在III型MPGN患者中，至少在疾病的慢性阶段，尽管C3值较低，但先前报道的Nft谱/存在情况并不总是能发现。
