Suzuki T, Ise Y, Tsuda M, Maeda J, Misawa M
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
Eur J Pharmacol. 1996 Oct 31;314(3):281-4. doi: 10.1016/s0014-2999(96)00723-6.
The present study examined a rapid and convenient model for evaluating nicotine dependence using the conditioned place preference paradigm. Rats were chronically infused subcutaneously with 9 mg/kg per day nicotine using an osmotic minipump. After nicotine infusion for 7 days, the nicotinic receptor antagonist mecamylamine produced a place aversion in nicotine-dependent rats, but not in acute nicotine-treated rats or sham-operated rats. These results suggest that the mecamylamine-precipitated withdrawal aversion in rats chronically treated with nicotine may result from physical dependence on nicotine, and may be useful for studying the physical dependence on nicotine.
本研究使用条件性位置偏爱范式检验了一种快速便捷的评估尼古丁依赖的模型。使用渗透微型泵每天给大鼠皮下慢性输注9毫克/千克尼古丁。在尼古丁输注7天后，烟碱受体拮抗剂美加明在尼古丁依赖的大鼠中引起位置厌恶，但在急性尼古丁处理的大鼠或假手术大鼠中未引起位置厌恶。这些结果表明，在长期用尼古丁处理的大鼠中，美加明诱发的戒断厌恶可能源于对尼古丁的身体依赖，并且可能有助于研究对尼古丁的身体依赖。
