Fonteyne W, Bauwens A, Jordaens L
Department of Cardiology, University Hospital Ghent, Belgium.
Clin Cardiol. 1996 Dec;19(12):967-8. doi: 10.1002/clc.4960191213.
Antimalarial drugs are well known for their cardiovascular toxicity. Quinine, the most famous antimalarial agent, mostly causes bradycardia. Quinidine, its dextrorotatory isomer, may cause 1:1 atrioventricular (AV) conduction during atrial flutter. The newly developed drug mefloquine was reported to have fewer cardiac side effects. We describe a 63-year-old male patient with atrial flutter in whom mefloquine use was associated with 1:1 AV conduction, and who then responded to therapy with digoxin and sotalol. The patient had a history of palpitations. This case report emphasizes that mefloquine should be used with caution in patients with a history of palpitations or underlying heart disease.
抗疟药物因其心血管毒性而闻名。奎宁是最著名的抗疟药，主要引起心动过缓。其右旋异构体奎尼丁在心房扑动时可能导致1:1房室传导。据报道，新开发的药物甲氟喹的心脏副作用较少。我们描述了一名63岁的心房扑动男性患者，使用甲氟喹后出现1:1房室传导，随后用地高辛和索他洛尔治疗有效。该患者有心悸病史。本病例报告强调，有悸病史或潜在心脏病的患者应谨慎使用甲氟喹。
