Lynch A M, Kapila R
Division of Infectious Diseases, New Jersey Medical School, Newark, USA.
Infect Dis Clin North Am. 1996 Dec;10(4):693-707. doi: 10.1016/s0891-5520(05)70322-6.
The incidence of overwhelming sepsis in asplenic patients is low. It carries, however, an unacceptably high morbidity rate and mortality rate. The risk of development is related to the age of the patient as well as the duration since and the reason for splenectomy. It may also occur in functionally hyposplenic states. The rapidly lethal clinical course demands intense efforts toward prevention by both physician and patient, rapid recognition within the initial medical setting, and aggressive intervention with broad-spectrum antibiotics and other supportive measures.
无脾患者暴发性脓毒症的发病率较低。然而，其发病率和死亡率高得令人难以接受。发病风险与患者年龄、脾切除术后的时长及原因有关。它也可能发生在功能性脾功能减退的状态下。这种迅速致命的临床病程要求医生和患者都要积极努力进行预防，在初始医疗环境中快速识别，并使用广谱抗生素和其他支持措施进行积极干预。
