Kim D S, Lee H K, Noh G W, Lee S I, Lee K Y
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 1996 Apr;37(2):125-30. doi: 10.3349/ymj.1996.37.2.125.
Serum IL-10 level in Kawasaki disease(KD) was tested. In the KD patients' sera during the acute phase, the levels of IL-10 were markedly elevated (122.0 +/- 39.1 pg/ml) compared to 3.7 +/- 1.7 pg/ml in the control subjects (p < 0.001). The serum IL-10 levels remained elevated in the subacute phase (16. 7 +/- 9.7 pg/ml, p < 0.001) and were restored to the normal levels(7.9 +/- 3.9 pg/ml) during the convalescent phase. In the patients with acute febrile disease, the serum IL-10 level increased significantly (34.4 +/- 14.1 pg/ml, p < 0.001) compared to that of the age-matched control subjects, but were not as high as in acute phase of KD(p < 0.005). This increase in serum IL-10 levels in KD may contribute to the up-regulation of humoral immunity and to the down-regulation of acute inflammation due to an increase in proinflammatory cytokines.
检测了川崎病（KD）患者的血清白细胞介素-10（IL-10）水平。在急性期KD患者的血清中，IL-10水平显著升高（122.0±39.1 pg/ml），而对照组为3.7±1.7 pg/ml（p<0.001）。在亚急性期血清IL-10水平仍升高（16.7±9.7 pg/ml，p<0.001），在恢复期恢复至正常水平（7.9±3.9 pg/ml）。在急性发热性疾病患者中，血清IL-10水平与年龄匹配的对照组相比显著升高（34.4±14.1 pg/ml，p<0.001），但不如KD急性期高（p<0.005）。KD患者血清IL-10水平的升高可能有助于体液免疫的上调以及由于促炎细胞因子增加导致的急性炎症的下调。
