Symon F A, Wardlaw A J
Department of Respiratory Medicine, University of Leicester School of Medicine, Glenfield Hospital, UK.
Thorax. 1996 Nov;51(11):1155-7. doi: 10.1136/thx.51.11.1155.
Selectins are adhesion receptors expressed by leucocytes, platelets, and endothelial cells. They mediate the initial binding of leucocytes to vascular endothelium in the post-capillary venules. This is an essential first step in leucocyte migration into tissue. The selectin family of adhesion receptors consists of three C-type lectins (E, P, and L selectin). Their ligands (counter structures) are sialylated and fucosylated carbohydrate molecules which, in most cases, decorate mucin-like glycoprotein membrane receptors. Studies using blocking monoclonal antibodies have shown that inhibition of selectin function can ameliorate a range of inflammatory processes, offering the possibility that antagonists of selectin function may be useful in the treatment of inflammatory lung diseases such as asthma.
选择素是白细胞、血小板和内皮细胞表达的黏附受体。它们介导白细胞与毛细血管后微静脉中的血管内皮的初始结合。这是白细胞迁移到组织中的关键第一步。黏附受体选择素家族由三种C型凝集素（E选择素、P选择素和L选择素）组成。它们的配体（对应结构）是唾液酸化和岩藻糖化的碳水化合物分子，在大多数情况下，这些分子修饰黏蛋白样糖蛋白膜受体。使用阻断性单克隆抗体的研究表明，抑制选择素功能可以改善一系列炎症过程，这表明选择素功能拮抗剂可能对治疗哮喘等炎症性肺病有用。
