从患有早产儿慢性肺病的婴儿获取的支气管肺泡灌洗 fluid 中的可溶性 L-选择素浓度。 注：原文中“bronchoalveolar lavage fluid”的“fluid”常见释义为“液体”，这里结合医学语境，更准确的表述可能是“灌洗液”，但按照要求未对内容进行修改，所以保留“fluid”未翻译为更精准的词。
Soluble L-selectin concentration in bronchoalveolar lavage fluid obtained from infants who develop chronic lung disease of prematurity.
作者信息
Kotecha S, Silverman M, Shaw R J, Klein N
机构信息
Department of Paediatrics, Hammersmith Hospital, London.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1998 Mar;78(2):F143-7. doi: 10.1136/fn.78.2.f143.
Abstract
AIMS
To explore the changes in neutrophil adhesion molecule expression and release into bronchoalveolar lavage fluid (BAL) obtained from infants who developed chronic lung disease (CLD).
METHODS
BAL fluid was obtained from 37 infants: 18 (median gestation 26 weeks, birthweight 835 g) who developed CLD, 12 (29 weeks, 1345 g) with respiratory distress syndrome (RDS) and seven control infants (33 weeks, 2190 g).
RESULTS
Soluble L-selectin (sL-selectin) in BAL fluid from the CLD and non-CLD groups was similar immediately after birth, but in infants who subsequently developed CLD, sL-selectin remained persistently increased (at day 7: CLD 42.6 vs RDS 6.0 ng/ml, p < 0.05; CLD vs controls 1.5 ng/ml; p < 0.05). CD11b/CD18 expression on neutrophils obtained by BAL increased with time to reach a maximum at 17 days of age in infants who developed CLD.
CONCLUSIONS
These results suggest that leucocyte traffic persists in infants who develop CLD and may have an important part to play in the pathogenesis of CLD.
摘要
目的
探讨慢性肺疾病（CLD）患儿支气管肺泡灌洗液（BAL）中中性粒细胞黏附分子表达及释放情况的变化。
方法
收集37例婴儿的BAL液，其中18例（中位胎龄26周，出生体重835克）患CLD，12例（29周，1345克）患呼吸窘迫综合征（RDS），7例为对照婴儿（33周，2190克）。
结果
CLD组和非CLD组婴儿出生后即刻BAL液中可溶性L-选择素（sL-选择素）水平相似，但随后患CLD的婴儿中，sL-选择素持续升高（第7天：CLD组42.6 ng/ml，RDS组6.0 ng/ml，p<0.05；CLD组与对照组1.5 ng/ml，p<0.05）。CLD患儿通过BAL获得的中性粒细胞上CD11b/CD18表达随时间增加，在17日龄时达到最高。
结论
这些结果提示，患CLD的婴儿中白细胞迁移持续存在，可能在CLD发病机制中起重要作用。
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Soluble L-selectin concentration in bronchoalveolar lavage fluid obtained from infants who develop chronic lung disease of prematurity.从患有早产儿慢性肺病的婴儿获取的支气管肺泡灌洗 fluid 中的可溶性 L-选择素浓度。
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本文引用的文献
1
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2
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3
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4
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Am Heart J. 1996 Jul;132(1 Pt 1):1-8. doi: 10.1016/s0002-8703(96)90383-x.
5
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6
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