Sato E, Saito I
Department of Neurosurgery, Kyorin University School of Medicine, Tokyo, Japan.
Acad Radiol. 1996 Nov;3(11):925-8. doi: 10.1016/s1076-6332(96)80301-1.
The introduction of low-osmolality contrast media has improved patient tolerance to angiographic procedures. However, nonionic contrast media may be associated with an increase in the risk of clot formation. The objective of this study was to test whether there is more clotting with nonionic agents than with ionic agents.
Ninety-eight patients undergoing transfemoral cerebral angiography were randomly assigned to receive ionic (ioxaglate) (n = 62) or nonionic (iopamidol or iohexol) (n = 36) contrast material. Incidence of clot formation was examined by observation of catheters.
Clot formation was found in 4.8% of patients in the ionic contrast material group and 22.2% of patients in the nonionic contrast material group (P < .05).
Nonionic contrast media resulted in a statistically significantly higher incidence of clot formation than ionic media during cerebral catheter angiography. These results suggest that ionic contrast media are preferable in patients with risk of thrombosis.
低渗造影剂的引入提高了患者对血管造影术的耐受性。然而，非离子型造影剂可能会增加血栓形成的风险。本研究的目的是测试非离子型造影剂与离子型造影剂相比是否会导致更多的凝血。
98例行股动脉脑血管造影的患者被随机分配接受离子型（碘克沙醇）（n = 62）或非离子型（碘帕醇或碘海醇）（n = 36）造影剂。通过观察导管检查血栓形成的发生率。
离子型造影剂组4.8%的患者出现血栓形成，非离子型造影剂组22.2%的患者出现血栓形成（P < .05）。
在脑血管造影术中，非离子型造影剂导致血栓形成的发生率在统计学上显著高于离子型造影剂。这些结果表明，对于有血栓形成风险的患者，离子型造影剂更可取。
